The Goblin Boss, Lord Gobb, has the added advantage of 20% physical and magic resistance. His Attack/HP scales with monsters (dependant on dungeon). This means that the APHEELSIK glyph has reduced effectiveness against him, and damage from all sources is reduced. This gives him an edge in any battle of attrition. There is literally no easy way to approach Gobb, but his resistance can be easily whittled down to nothing with a liberal use of Might or Piercing Wand or boons that reduce resistances.